The Mehta Family Centre for Engineering in Medicine Indian Institute of Technology, Kanpur

Molecular Medicine and Engineering

 

Overview

An existing research area at BSBE that encompasses attributes of fundamental biology, translational research and product development comes under the broad theme of Molecular Medicine and Engineering. BSBE currently hosts excellent research programs on cancer biology, gene therapy, chemical, synthetic and computational biology, which are utilizing a broad repertoire of cutting-edge approaches to address frontier research questions in the respective fields. More importantly, there is an unparalleled opportunity for us to expand our already strong footprint in this particular thematic direction by embarking on rapidly evolving, next-generation research sub-themes, and even breaking new grounds with respect to inception of currently lacking ambitious frameworks of interdisciplinary science.

 

Onco-targeting by precision medicine

One of the existing strengths at BSBE is a world-class program in cancer biology with a long-term goal of developing novel therapeutics, especially for cancers predominatly present in Indian sub-continent. Cancer is a clinically heterogeneous disease manifested by intra-tumoral as well as inter-patient molecular variability.

 

Genome and Cellular Engineering

Another major research strength at BSBE where we have unique edge with a multidisciplinary set of expertise is in the broad theme of molecular therapeutics. For example, the importance of gene and cell therapy for treating disorders with specific genetic defects has been recognized for long.

 

 

Chemical and synthetic approaches to drug discovery

One more research theme where BSBE faculty are amongst National and International leaders is chemical, structural and computation biology of important drug-targets involved in various types of human disorders.

 

 

Neuroscience and Neuroengineering

Understanding the brain is the ultimate challenge for the 21st century. Compared to other organs and systems in the body, the brain is by far the least understood. To be successful, neuroscience needs an amalgamation of techniques from multiple disciplines.

 

Grand Challenge

Overall, we envision that the upcoming phase of our research program spanning the next ten years or so, will involve faculty from the molecular medicine and engineering program from the four thematic areas (Chemical and synthetic approaches to drug discovery, Onco-targeting by precision medicine, genome and cellular engineering and Neuroscience and neuroengineering) to synergize their efforts to develop enabling bench-to-bedside solutions for the treatment of solid tumors (oral, breast, prostate and liver cancer) and neurological disorders. The focus of this initiative will be to develop local healthcare solutions to these conditions, including low cost diagnostics and therapeutics by employing a range of innovative genomic and proteomic analysis, orphan small-molecule and receptor scanning approach and development of synthetic gene/drug delivery systems. Long-term, we expect that this multidisciplinary research initiative in cancer/neurological disorder therapeutics will have a societal impact by

 

generation of high-quality intellectual property, specialized technical expertise and innovative products that will significantly improve the pace and output of research and development in these fields in India. This will be further supplemented by the proposed post-graduate program in Molecular Medicine and Engineering as an academic initiative of this program, to further train and disseminate this knowledge to the Nextgen leaders. Such a hub of excellence, once established, will seamlessly integrate into the proposed medical school at IIT-K to further drive and promote our vision to be leaders in this field.